منابع مشابه
Intimal smooth muscle cells: the context-dependent origin.
The sixth-century BC Chinese military general Sun Tzu underscored the dangers of overconfidence in strategy. A similar view has been shared by other thinkers and applied further to various contexts other than the military. A major goal of the medical sciences is to develop effective, wellrefined therapies. Accomplishing this task requires a comprehensive understanding of the biology of each com...
متن کاملDiverse origin of intimal cells: smooth muscle cells, myofibroblasts, fibroblasts, and beyond?
The formation of vascular lesions is invariably associated with the accumulation of mesenchymal cells and their products in the intima, which either compromise the vessel lumen or contribute to retention of atherogenic molecules (reviewed in References 1 and 2).1,2 As a result, pathological intimal hyperplasia is pivotal in the development of a wide range of clinical conditions, which are assoc...
متن کاملPPARg attenuates intimal hyperplasia by inhibiting TLR4-mediated inflammation in vascular smooth muscle cells
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . PPARg attenuates intimal hyperplasi...
متن کاملIntimal Smooth Muscle Cells as a Target for Peroxisome Proliferator-Activated Receptor- Ligand Therapy
Activation of the nuclear receptor/transcription factor, peroxisome proliferator-activated receptor (PPAR ), is a newly defined target for limiting vascular pathologies. PPAR is expressed in human and animal models of vascular disease, with particularly high levels being present in the cells of the neointimal microenvironment. In the present study, we show that intimal smooth muscle cells in vi...
متن کاملThe flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells.
Quercetin, the most abundant dietary flavonol, exerts vasodilator, anti-hypertensive, and anti-atherogenic effects and reduces the vascular remodelling associated with elevated blood pressure. Here, we have compared the effects of quercetin in intimal- and medial-type rat vascular smooth muscle cells (VSMC) in culture. After 48 h, quercetin reduced the viability of a polyclonal intimal-type cel...
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ژورنال
عنوان ژورنال: Circulation
سال: 2010
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.110.986968